If you’re dealing with frustrating and unpredictable issues like your 2006 Isuzu I-350 stalling, running rough, or refusing to start, a failing Powertrain Control Module (PCM) is often the culprit. As the brain of your truck’s engine and transmission, when the PCM starts to fail, it can cause a cascade of problems that are difficult to diagnose. This isn’t just an inconvenience; it’s a reliability issue that can leave you stranded. I’ve seen it countless times in the shop: a vehicle comes in with a laundry list of seemingly unrelated error codes, and after hours of chasing down sensors and wiring, the root cause points back to the engine computer itself.
This is your direct-fit, reliable solution. We are offering a genuine replacement 2006 Isuzu I-350 Powertrain Control Module that comes fully programmed to your truck’s specific Vehicle Identification Number (VIN). This critical programming step ensures that all factory settings for your engine, transmission, and emissions systems are perfectly matched, just as they were when your truck left the assembly line. We handle all the complex programming work before we ship, so you receive a part that is ready for installation right out of the box. You get the latest GM software updates, which can often resolve underlying drivability issues you didn’t even know were software-related.
From the Diagnostic Bay: A Tricky Intermittent Stall
A customer brought in a 2006 GMC Canyon, a sister truck to the I-350, with an intermittent stalling problem that no one could solve. It would run fine for days, then suddenly die at a stoplight. No consistent check engine codes were stored, just a few random communication errors. We checked fuel pressure, ignition components, and sensors—all tested fine. From experience, I know these intermittent electronic gremlins often lead back to the main computer. We connected a data logger and finally caught it: just before a stall, the PCM’s 5-volt reference signal would drop out completely. This single failure was shutting down multiple critical sensors at once, causing the engine to quit. Swapping in a properly programmed PCM like this one solved the problem permanently. The customer went from being afraid to drive his truck to having his reliable workhorse back.
Is Your Truck Exhibiting These PCM Failure Signs?
A failing PCM can manifest in various ways. If you’re noticing any of the following, it might be time for a replacement:
- ✔ Persistent Check Engine Light (CEL) that won’t clear
- ✔ Stored diagnostic trouble codes (DTCs) like P0601, P0606, or U0100
- ✔ Engine cranks but refuses to start
- ✔ Rough or erratic idling
- ✔ Unexplained drop in fuel economy
- ✔ Harsh or incorrect gear shifting
- ✔ Failure to pass an emissions inspection
A Straightforward Guide to Installation
Installing your new 2006 Isuzu I-350 Powertrain Control Module is a job most DIYers can handle in their own driveway. No special dealer tools are required.
- Safety First: Disconnect the negative terminal from your vehicle’s battery to prevent any electrical shorts.
- Locate the PCM: On the Isuzu I-350, the PCM is typically located on the right-hand (passenger side) of the firewall in the engine bay.
- Disconnect Connectors: Carefully release the locking tabs and unplug the wiring harness connectors from the old module. Inspect the connectors for any corrosion or damage.
- Remove the Old Module: Unbolt the old PCM from its mounting bracket. It’s usually held in by a few bolts or nuts.
- Install the New Module: Mount your new, pre-programmed PCM onto the bracket and secure it.
- Reconnect Everything: Plug the wiring harnesses back into the new module until they click securely in place. Reconnect your battery terminal.
- Final Step: In some cases, a security relearn procedure may be necessary, which can typically be done by cycling the key. Instructions are readily available online for your specific model.
Verified Vehicle Compatibility
This module is a direct replacement for a wide range of GM trucks and SUVs, ensuring perfect function. Please verify your vehicle is on this list. This part is compatible with the following part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.
- Chevrolet Colorado 2004-2006 (RH firewall)
- GMC Canyon 2004-2006 (RH firewall)
- Hummer H3 2006 (RH firewall)
- Isuzu I-280 2006 (RH firewall)
- Isuzu I-350 2006 (RH firewall)
- Buick Rainier 2006 (4.2L, LH engine)
- Chevrolet Trailblazer 2006 (4.2L, LH engine)
- Chevrolet Trailblazer EXT 2006 (4.2L, LH engine)
- GMC Envoy 2006 (4.2L, LH engine)
- GMC Envoy XL 2006 (4.2L, LH engine)
- Isuzu Ascender 2006 (4.2L, LH engine)
- Saab 9-7x 2006 (6 cylinder, LH engine)
Frequently Asked Questions
What do I need to do after I purchase?
After you complete your purchase, you must provide us with your vehicle’s 17-digit VIN. We cannot program and ship the module without it. You can add the VIN to the notes section at checkout or reply to your order confirmation email.
Is this part truly plug-and-play?
Yes. Because we program it to your VIN before shipping, it arrives ready to be installed without requiring a trip to the dealership for further programming. In some rare cases, a simple key-cycle security relearn may be needed.
Will this fix my truck’s check engine light?
If the check engine light and drivability problems are caused by a faulty PCM, then this part is the correct solution. It resolves internal processor faults (like DTC P0606) and other module-specific errors.
How do I find my VIN?
Your Vehicle Identification Number (VIN) is located on a tag on the driver’s side of the dashboard (visible through the windshield) and on the sticker in the driver’s side door jamb. It is also printed on your vehicle’s registration and insurance documents.
Do I need to return my old PCM?
No core charge or return is required for this part. You can recycle your old module locally.