Restore Your Truck’s Performance and Reliability
Is your 2006 Isuzu I-350 acting up? Experiencing frustrating issues like a persistent Check Engine Light, erratic engine behavior, poor fuel mileage, or even a no-start condition? The Powertrain Control Module (PCM), the central computer of your vehicle, is often the culprit. When it fails, it can cause a cascade of problems that are difficult to diagnose. This isn’t just an inconvenience; it’s a reliability issue that can leave you stranded. As a technician with over two decades of experience, I’ve seen firsthand how a failing PCM can mimic other problems, leading to wasted time and money on unnecessary repairs.
This is your direct-fit, hassle-free solution. We are offering a replacement 2006 Isuzu I-350 PCM that comes fully programmed to your truck’s specific Vehicle Identification Number (VIN). This critical step ensures that the module communicates perfectly with your engine, transmission, and all other onboard systems, just as the original did. We load the latest GM-authorized software updates, which can often resolve underlying drivability issues the factory may have corrected after your truck was built. Forget expensive dealership visits and the added cost of programming—this module arrives ready for installation.
A Technician’s Notebook: The Intermittent Stall Case
I remember a 2006 Chevy Colorado (which uses this exact same PCM) that came into my bay with a complaint of intermittent stalling at stoplights. The owner had already replaced the fuel pump and cleaned the throttle body, but the problem persisted. No hard codes were stored, just a history U0100 (Lost Communication with ECM/PCM). After checking all the power and ground connections to the PCM, we noticed that a gentle tap on the module itself could sometimes trigger the stall. This pointed to an internal failure. We installed a VIN-programmed 2006 Isuzu I-350 PCM (the compatible part), and the truck ran perfectly. The issue wasn’t fuel or air; it was the brain itself failing under specific conditions.
Is Your Truck Showing These Symptoms?
A failing PCM can manifest in various ways. If you’re noticing any of the following, this module is likely the solution you need:
- ✔ Check Engine Light is illuminated with communication or internal processor codes (e.g., P0601, P0606, U0100).
- ✔ The engine cranks but refuses to start.
- ✔ Unexplained drop in fuel economy.
- ✔ Harsh or erratic automatic transmission shifting.
- ✔ Engine stalling, stumbling, or misfiring.
- ✔ Other modules on the vehicle (like the ABS or BCM) report a loss of communication with the PCM.
A Straightforward Guide to Installation
Replacing the PCM on these trucks is a job most DIYers can handle with basic tools. This module is located on the right-hand (passenger side) of the firewall in the engine bay.
- Safety First: Disconnect the negative terminal from your vehicle’s battery and wait at least 15 minutes for the system capacitors to discharge.
- Locate the PCM: Open the hood and find the module on the passenger-side firewall. It will have several large electrical connectors.
- Disconnect Connectors: Carefully release the locking tabs and unplug all electrical harnesses from the old PCM. Inspect the connectors for any corrosion or bent pins.
- Remove the Old Module: Unbolt the PCM from its mounting bracket. Keep the hardware as you will need it for the new module.
- Install the New PCM: Mount your new, pre-programmed PCM onto the bracket and secure it with the original hardware.
- Reconnect Everything: Plug the electrical connectors firmly back into the new module until they click and the locking tabs are secure. Reconnect the negative battery terminal.
- Final Step: Some vehicles may require a security relearn procedure, which typically involves turning the key to the ‘ON’ position for 10-15 minutes. Consult your vehicle’s service information for specific steps if needed.
Verified Vehicle Compatibility
This Electronic Control Module is a guaranteed fit for the following makes and models. Please verify your vehicle and engine options below. This part replaces a wide range of original part numbers, including 12569773, 12588650, 12597521, 19209820, and many more.
- Chevrolet Colorado 2004-2006 (RH firewall)
- GMC Canyon 2004-2006 (RH firewall)
- Hummer H3 2006 (RH firewall)
- Isuzu I-280 2006 (RH firewall)
- Isuzu I-350 2006 (RH firewall)
- Buick Rainier 2006 (4.2L, LH engine)
- Chevrolet Trailblazer & Trailblazer EXT 2006 (4.2L, LH engine)
- GMC Envoy & Envoy XL 2006 (4.2L, LH engine)
- Isuzu Ascender 2006 (4.2L, LH engine)
- Saab 9-7X 2006 (6-Cylinder, LH engine)
Frequently Asked Questions
How does the VIN programming process work?
After you place your order, you will need to provide us with your vehicle’s 17-digit VIN. Our technicians use this number to access the latest official GM software for your specific vehicle configuration and program the module before it ships. This ensures it’s a true plug-and-play part.
Do I need to send my old PCM back?
There is no core charge or requirement to return your old module for this particular part. You can keep it or dispose of it responsibly.
Will this fix my specific problem?
This module is a direct solution for a failed PCM. If your vehicle has been properly diagnosed with a faulty PCM (e.g., with codes like P0601 or confirmed communication loss), then this part will resolve those issues. It will not fix problems related to other faulty sensors or mechanical components.
Is any other programming needed after installation?
In most cases, no. Because we program it to your VIN, it’s ready to go. However, some GM vehicles may require a simple, key-on security relearn procedure that does not require any special tools. We recommend checking your vehicle’s service manual for specifics.
How do I find my part number to confirm a match?
You can find the part number on a sticker on your original PCM. However, since this unit replaces many different part numbers, the most important thing is to match your vehicle’s year, make, and model from our compatibility list. The VIN programming ensures it works regardless of the original part number.