If you’re dealing with frustrating engine problems in your 2006 Isuzu I-350—like a persistent check engine light, erratic shifting, or a no-start condition—the root cause is often a failing Powertrain Control Module (PCM). As the central computer of your truck, a faulty PCM can create a cascade of issues that are difficult to diagnose. This replacement 2006 Isuzu I-350 PCM is your direct, reliable solution to restore your vehicle’s performance and get you back on the road with confidence.
We take the guesswork and extra cost out of the repair. Unlike sourcing a module from a junkyard or a generic parts store, this unit comes fully programmed to your truck’s specific Vehicle Identification Number (VIN). We install the latest GM-authorized software updates before it even leaves our facility. This means no expensive trip to the dealership for programming—it’s ready for installation right out of the box.
A Technician’s Notebook
I once had a 2006 Chevy Colorado (which shares the same platform as the I-350) come into the shop on a tow truck. The owner had already replaced the fuel pump and crankshaft position sensor trying to solve an intermittent stalling problem that eventually became a full no-start. The codes were all over the place—communication errors (U-codes) and a random misfire code. After checking the main power and ground circuits to the PCM, I knew where to look. We swapped in a programmed PCM, and the truck fired up instantly and ran perfectly. It’s a classic case where the vehicle’s ‘brain’ was failing, sending the owner on an expensive parts chase. A correct diagnosis starts with the central controller.
Is Your Truck Showing These Symptoms?
A failing PCM can manifest in numerous ways. If you’re experiencing any of the following, it’s a strong indicator that your module needs replacement:
- ✔ Persistent Check Engine Light (CEL)
- ✔ Diagnostic Trouble Codes (DTCs) related to internal module failure, such as P0601, P0602, P0606
- ✔ Vehicle won’t start or is very hard to start
- ✔ Poor or erratic automatic transmission shifting
- ✔ Noticeable decrease in fuel economy
- ✔ Engine stalling, stumbling, or running rough at idle
- ✔ Communication errors with other vehicle modules
A Straightforward Guide to Installation
Installing your new 2006 Isuzu I-350 PCM is a manageable job for a DIYer with basic tools. Follow these steps carefully for a successful replacement.
- Safety First: Always disconnect the negative terminal from your truck’s battery and wait at least 10 minutes to allow the system to fully discharge.
- Locate the Module: On the 2006 Isuzu I-350, the PCM is typically located on the right-hand (passenger) side of the firewall in the engine bay.
- Disconnect the Connectors: Carefully unlatch and remove the electrical wiring harness connectors from the old PCM. Inspect them for any corrosion or damage.
- Remove the Old PCM: Unbolt the old module from its mounting bracket. It’s usually held in place by a few small bolts.
- Install the New PCM: Mount the new, pre-programmed module in the same location and secure it with the original bolts.
- Reconnect Everything: Firmly plug the wiring harness connectors into the new PCM until they click into place. Reconnect the negative battery terminal.
- Perform Security Relearn: In many cases, you may need to perform a security relearn procedure to sync the new PCM with your vehicle’s anti-theft system. This typically involves turning the key to the ‘ON’ position for 10-15 minutes. Consult your owner’s manual or a reliable online resource for the specific procedure for your truck.
Will This Fit My Truck?
This module is a guaranteed fit for the following vehicles. Please verify your model and engine options. This part directly replaces part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.
- Chevrolet Colorado 2004-2006 (RH firewall)
- GMC Canyon 2004-2006 (RH firewall)
- Hummer H3 2006 (RH firewall)
- Isuzu I-280 2006 (RH firewall)
- Isuzu I-350 2006 (RH firewall)
- Buick Rainier 2006 (4.2L, LH engine)
- Chevrolet Trailblazer 2006 (4.2L, LH engine)
- Chevrolet Trailblazer EXT 2006 (4.2L, LH engine)
- GMC Envoy 2006 (4.2L, LH engine)
- GMC Envoy XL 2006 (4.2L, LH engine)
- Isuzu Ascender 2006 (4.2L, LH engine)
- Saab 9-7X 2006 (6 cylinder, LH engine)
Frequently Asked Questions
Do I need to send my old PCM in?
No core charge or return is required for this part. You can purchase it outright.
How do I provide my VIN for programming?
After you complete your purchase, you will receive instructions on how to send us your vehicle’s 17-digit VIN. We cannot ship the module until we receive and validate your VIN, as this is crucial for correct programming.
Is this a simple plug-and-play installation?
Yes, because we program it to your VIN, it is designed to be a direct replacement. However, as noted in the installation guide, you will likely need to perform a simple security relearn procedure, which does not require special tools.
Will this 2006 Isuzu I-350 PCM fix my specific problem?
This module is the definitive fix for problems caused by a faulty PCM itself. While it resolves a wide range of common symptoms, it’s essential to ensure your vehicle’s issues are not caused by other failing components like sensors or wiring. If you have codes like P0601 or P0606, a PCM replacement is the correct repair.
What if my part number isn’t listed?
The part numbers listed are the most common interchanges. If your original module has a different number but your vehicle matches the fitment list, please contact us with your VIN. We can verify compatibility for you.