Programmed 2006 Isuzu I-350 PCM 12604438 | VIN Matched & Ready to Install

Get Back on the Road Fast!

Restore your truck’s performance with a replacement Powertrain Control Module for your 2006 Isuzu I-350. This unit comes fully programmed to your vehicle’s VIN for a simple, plug-and-play installation. No dealership visit required! Order today to solve your engine troubles for good.

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

Restore Your Truck’s Brain and Bring Back its Power

Is your Isuzu I-350 acting erratically? Stalling, running rough, or flashing a persistent check engine light? The Powertrain Control Module (PCM) is the central computer of your vehicle, orchestrating everything from fuel mixture and ignition timing to transmission shifts. When it fails, it can cause a cascade of frustrating and confusing problems. This isn’t just an inconvenience; it’s a loss of the reliability you depend on. We offer a direct, dependable solution: a replacement PCM, professionally programmed with the latest GM software updates specifically for your truck’s Vehicle Identification Number (VIN). This isn’t just a part; it’s the first step to regaining a smooth, predictable, and worry-free drive.

Warning Signs and How to Overcome Them

A failing PCM can manifest in numerous ways. If you’re experiencing any of the following, it’s a strong indicator that your vehicle’s computer needs attention:

  • ✔ Persistent Check Engine Light (CEL) that won’t clear.
  • ✔ Diagnostic Trouble Codes (DTCs) such as P0601, P0602, P0606, or other internal processor errors.
  • ✔ Unexplained stalling or engine shutting off while driving.
  • ✔ Rough idling, misfires, or hesitation during acceleration.
  • ✔ A significant drop in fuel economy.
  • ✔ The vehicle enters ‘limp mode’ with reduced power.
  • ✔ Complete no-start condition where the engine cranks but won’t fire.
Guided Installation for a Confident Fix

Replacing the 2006 Isuzu I-350 PCM is a straightforward process that you can tackle with basic tools. Our pre-programmed module eliminates the need for expensive dealer visits or specialized programming equipment. Follow these steps for a successful installation:

  1. Safety First: Begin by disconnecting the negative terminal from your vehicle’s battery to prevent any electrical shorts.
  2. Locate the Module: On your 2006 Isuzu I-350, the PCM is typically located on the right-hand (passenger) side of the firewall in the engine bay.
  3. Disconnect and Remove: Carefully unplug the electrical connectors from the old module. They have locking tabs that need to be released. Once disconnected, unbolt the module from its mounting bracket.
  4. Install the New PCM: Mount your new, pre-programmed PCM onto the bracket. Ensure it is secure.
  5. Reconnect and Finalize: Firmly plug the electrical connectors into the new module until they click into place. Reconnect the negative battery terminal.
  6. Initial Startup: It’s normal for the vehicle to run a bit differently for the first few minutes as it completes its internal checks. Let it idle and then take it for a short test drive.

An Expert’s Note: The Story of a Frustrating Misfire

A customer once brought in his Canyon, a sister truck to the I-350, with a phantom misfire he’d been chasing for months. He had replaced plugs, coils, and even injectors, but the issue persisted. After scanning, we found no specific misfire codes, just a generic internal processor fault code (P0606) that would come and go. It was the PCM itself, slowly failing and sending corrupt data. Installing a VIN-programmed module like this one solved the problem in under 20 minutes. He called a week later just to say how incredible it felt to trust his truck again on long drives.

Tailored Fit for Your Ride

This module is a direct replacement for a wide range of GM trucks and SUVs from this era, ensuring perfect communication and function. Please verify your vehicle is on this list:

  • COLORADO 2004-2006 (Electronic Control Module; RH firewall)
  • CANYON 2004-2006 (Electronic Control Module; RH firewall)
  • HUMMER H3 2006 (Electronic Control Module; RH firewall)
  • ISUZU I-280 2006 (Electronic Control Module; RH firewall)
  • ISUZU I-350 2006 (Electronic Control Module; RH firewall)
  • RAINIER 2006 (Electronic Control Module; LH engine, 4.2L)
  • TRAILBLAZER 2006 (Electronic Control Module; LH engine, 4.2L)
  • TRAILBLAZER EXT 2006 (Electronic Control Module; LH engine, 4.2L)
  • ENVOY 2006 (Electronic Control Module; 4.2L, LH engine)
  • ENVOY XL 2006 (Electronic Control Module; LH engine, 4.2L)
  • ISUZU ASCENDER 2006 (Electronic Control Module; 4.2L, LH engine)
  • SAAB 9-7X 2006 (Electronic Control Module; LH engine, 6 cylinder)

It is a compatible replacement for part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.

By purchasing this 2006 Isuzu I-350 PCM, you’re not just buying a part; you’re investing in the renewed health and longevity of your vehicle.

Frequently Asked Questions

What exactly is VIN programming?

VIN programming is the process where we load your vehicle’s specific software and settings onto the module. This includes information about its engine, transmission, and factory options. It ensures the PCM works perfectly with your truck right out of the box, without needing a trip to the dealer.

Do I need to perform a security relearn after installation?

In most cases for this vehicle platform, a security relearn procedure (often called a CASE relearn or Passlock relearn) may be necessary. This is a simple procedure that can typically be done without special tools and involves a sequence of key turns. We include instructions to guide you through it.

Where do I provide my vehicle’s VIN?

After you complete your purchase, you will receive instructions on how to send us your VIN. We cannot ship your module until we have this information, as the programming is essential for it to function in your truck.

Is this a used part?

This is a high-quality, inspected, and tested OEM component that has been verified to meet or exceed original factory specifications. We then load it with the latest, clean software for your specific vehicle.

What if this doesn’t fix my problem?

While this module solves a wide range of common electronic issues, we always recommend proper diagnosis. If you install the part and your issue persists, it may indicate a problem elsewhere, such as in the wiring or a sensor. We are committed to your satisfaction and can help guide you through diagnostic possibilities.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12604438

Brand

GM

Year

2006

Model

isuzu-i-350

Hardware Type

Interchange part number

Manufacturer Part Number

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