Programmed 2006 Isuzu I-280 PCM | 12604438 | Plug-and-Drive Solution

Get Your Truck Running Right Again!

This is a direct-fit Powertrain Control Module for your 2006 Isuzu I-280, pre-programmed to your vehicle’s VIN for a simple, plug-and-play installation. Restore performance and solve frustrating electrical issues. Provide your VIN at checkout and get back on the road fast!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

End Your Engine Troubles and Drive with Confidence Again

Is your truck suffering from a mysterious ailment? A persistent check engine light, rough idling, stalling, or transmission shifting problems can turn every drive into a stressful ordeal. These are classic signs of a failing Powertrain Control Module (PCM), the vital computer that manages your engine’s performance. Instead of facing a costly and time-consuming trip to the dealership, take control of your repair with this professionally programmed 2006 Isuzu I-280 PCM. We flash this module with the latest GM software updates, tailored specifically to your vehicle’s unique VIN. This isn’t just a replacement part; it’s a restoration of your truck’s original performance and reliability, delivered right to your door.

Warning Signs and How to Overcome Them

If you’re experiencing any of the following, a faulty engine computer is the likely culprit. This module is the definitive solution for:

  • ✔ Unexplained Check Engine Light illumination, especially with communication-related codes (e.g., P0601, P0606).
  • ✔ Poor fuel economy that has gradually worsened over time.
  • ✔ The engine cranks but refuses to start, or starts and immediately stalls.
  • ✔ Harsh or erratic automatic transmission shifting.
  • ✔ A noticeable loss of power and sluggish acceleration.
  • ✔ Failure to pass state emissions testing due to module-related faults.

A Mechanic’s Story: The Frustrated Fleet Owner

“A local landscaper brought in his ’06 Colorado—a truck identical in its electronics to your Isuzu. It was randomly stalling at job sites, costing him time and money. The dealer quoted him over a thousand dollars for a new computer and programming. He was at his wit’s end. We ordered one of these pre-programmed modules for him. The next morning, it took me less than 20 minutes to swap it out. The truck fired right up and ran smoother than it had in years. He was back in business the same day for a fraction of the cost. That’s the power of getting the right part, ready to go.”

Guided Installation to Restore Peace of Mind

You don’t need to be a master mechanic to complete this repair. Our goal is to empower you with a straightforward, plug-and-drive solution. Follow these simple steps for a successful installation of your new 2006 Isuzu I-280 PCM.

  1. Safety First: Disconnect the Battery
    Before you begin, always disconnect the negative terminal from your vehicle’s battery and secure it away from the post to prevent any accidental electrical contact.
  2. Locate the Old Module
    On your Isuzu I-280 (and similar models like the Colorado/Canyon), the PCM is typically located on the right-hand (passenger) side of the firewall in the engine bay.
  3. Disconnect the Wiring Harnesses
    Carefully unplug the electrical connectors from the old module. There are usually release tabs that need to be depressed. Inspect the connectors for any corrosion or damage and clean them if necessary.
  4. Remove the Old PCM
    Unbolt the old module from its mounting bracket. It’s usually held in place by a few small bolts. Set it aside.
  5. Install the New Module
    Mount your new, pre-programmed PCM onto the bracket and secure it with the bolts. Reconnect the wiring harnesses, ensuring they click securely into place.
  6. Reconnect and Start
    Reconnect the negative battery terminal. Your vehicle may need to perform a security relearn procedure, which typically involves turning the key to the ‘ON’ position for 10-15 minutes before starting. Consult your owner’s manual for specifics. Once complete, start the engine and enjoy a smoother, more responsive drive!

Tailored Fit for Your Ride

This module is a direct-fit replacement for a wide range of GM vehicles, ensuring perfect communication and function. Please verify your vehicle is on this list and that your original part number is one of the compatible numbers provided. This programmed 2006 Isuzu I-280 PCM is the correct component for the following vehicles:

  • 2004-2006 Chevrolet Colorado
  • 2004-2006 GMC Canyon
  • 2006 Buick Rainier (4.2L)
  • 2006 Hummer H3
  • 2006 Isuzu Ascender (4.2L)
  • 2006 Isuzu I-280
  • 2006 Isuzu I-350
  • 2006 Chevrolet Trailblazer & Trailblazer EXT (4.2L)
  • 2006 GMC Envoy & Envoy XL (4.2L)
  • 2006 Saab 9-7X (6 cylinder)

This unit replaces part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.

Frequently Asked Questions

Is any additional programming required after I install it?

No. We program the module to your vehicle’s specific VIN before shipping. In most cases, it is a plug-and-drive installation, though some vehicles may require a simple security relearn procedure (often called a key cycle) which you can easily do yourself in your driveway.

What is a VIN and why do you need it?

The VIN, or Vehicle Identification Number, is a unique 17-digit code for your truck. It contains critical information about your vehicle’s specific options, engine type, and security system. Providing your VIN allows us to load the exact correct software so the module works perfectly with your truck.

How long does the programming process take?

Once we receive your order and VIN, we typically program and ship the module within 1-2 business days. Our goal is to get you back on the road as quickly as possible.

What if my original part number isn’t on your list?

If your part number is not listed, please contact us with your vehicle’s year, make, model, and VIN. We can verify compatibility and ensure you receive the correct computer for your application.

Is this a quality, tested part?

Absolutely. Every module undergoes a thorough inspection and testing process to ensure it meets or exceeds original equipment performance standards. We stand behind our work to provide you with a reliable, long-lasting solution.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12604438

Brand

GM

Year

2006

Model

isuzu-i-280

Hardware Type

Interchange part number

Manufacturer Part Number

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