Programmed 2006 Isuzu I-280 PCM | 12591648 | Plug & Drive Ready

Restore Your Isuzu’s Drivability!

Get your 2006 Isuzu I-280 running smoothly again with this VIN-programmed Powertrain Control Module. It arrives ready to install with the latest GM software, solving common issues like rough idling, poor shifting, and no-start conditions. Order today for a reliable, plug-and-play solution!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

Restore Peak Performance to Your Truck

Is your truck suffering from puzzling issues like a persistent check engine light, rough idling, or frustrating stalling? These are classic signs that the brain of your engine, the Powertrain Control Module (PCM), may be failing. This isn’t just an annoyance; it affects your vehicle’s reliability, fuel economy, and overall safety. This replacement module is the definitive solution, arriving pre-programmed to your vehicle’s unique VIN. We take care of the complex flashing process, so you receive a component that’s ready to restore the smooth, dependable operation you expect.

Warning Signs Your PCM Needs Attention

A failing engine computer can manifest in various ways. If you’re experiencing any of the following, it’s time to investigate. This module is engineered to solve these exact problems:

  • ✔ Persistent Check Engine Light (CEL) that won’t go away.
  • ✔ Diagnostic Trouble Codes (DTCs) stored, such as P0601, P0602, or P0606.
  • ✔ Unexplained drops in fuel mileage.
  • ✔ The engine cranks but refuses to start.
  • ✔ Harsh or erratic automatic transmission shifting.
  • ✔ Stumbling, hesitation, or stalling during acceleration or at idle.

Guided Installation for a Confident Repair

Replacing the PCM is a straightforward job you can tackle with basic hand tools. Follow these steps to get your truck back in top form and regain that worry-free drive. This guide specifically covers the 2006 Isuzu I-280 PCM installation, which is similar across many compatible models.

  1. Safety First: Disconnect the Battery. Before you begin, always disconnect the negative terminal of your vehicle’s battery to prevent any electrical shorts.
  2. Locate the Old Module. On most of these trucks, including the I-280, Colorado, and Canyon, the PCM is located on the right-hand (passenger) side of the firewall in the engine bay.
  3. Disconnect the Harnesses. Carefully unplug the electrical connectors from the old PCM. There are typically release tabs that need to be depressed or levers that need to be swung open. Do not force them.
  4. Remove the Old Unit. Unbolt the PCM from its mounting bracket. Keep the hardware safe, as you’ll need it for the new module.
  5. Install the New PCM. Mount your new, pre-programmed PCM onto the bracket and secure it with the original hardware.
  6. Reconnect Everything. Plug the wiring harnesses back into the new module until they click securely in place. Reconnect the negative battery terminal.
  7. Perform Security Relearn. Your vehicle may require a security relearn procedure to recognize the new PCM. This typically involves turning the key to the ‘ON’ position for 10 minutes, then ‘OFF’ for 10 seconds, and repeating this cycle three times. This allows the anti-theft system to sync with the new computer.

Expert Tip: Check Your Grounds

Before installing your new PCM, take a moment to inspect and clean the main engine and chassis ground connections. A corroded or loose ground wire can cause erratic voltage, mimicking the symptoms of a failed computer and potentially damaging the new unit. A few minutes with a wire brush can save you a major headache.

Tailored Fit for Your Ride

This module is a direct-fit replacement, programmed specifically for your vehicle. It is compatible with a wide range of GM trucks and SUVs. Please verify your model and year from the list below:

  • Chevrolet Colorado: 2004-2006
  • GMC Canyon: 2004-2006
  • Hummer H3: 2006
  • Isuzu I-280: 2006
  • Isuzu I-350: 2006
  • Buick Rainier: 2006 (4.2L)
  • Chevrolet Trailblazer & Trailblazer EXT: 2006 (4.2L)
  • GMC Envoy & Envoy XL: 2006 (4.2L)
  • Isuzu Ascender: 2006 (4.2L)
  • Saab 9-7X: 2006 (6 cylinder)

This unit replaces part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, and more.

Frequently Asked Questions

Do I need to do any programming myself?

No. We handle all the programming before shipping. Simply provide us with your vehicle’s VIN during checkout, and we will flash the module with the latest GM-certified software for your specific vehicle. It arrives ready to install.

What is a security relearn and is it difficult?

The security relearn, or anti-theft relearn, is a simple procedure that syncs the new PCM to your vehicle’s security system. It typically takes about 30 minutes and only requires you to cycle the ignition key. We include easy-to-follow instructions with your order.

Where is the PCM located on my 2006 Isuzu I-280?

On the 2006 Isuzu I-280 and similar platforms like the Chevy Colorado, the PCM is mounted on the right-hand (passenger side) of the firewall in the engine compartment.

Will this fix my check engine light?

If the check engine light is caused by an internal failure of the PCM (e.g., codes like P0601), then yes, this part is the correct solution. It’s always best to have the codes professionally diagnosed to confirm the PCM is the root cause before ordering.

What information do you need from me?

After you place your order, we will need your 17-digit Vehicle Identification Number (VIN). This allows us to program the module with the exact software and calibrations for your truck’s engine, transmission, and options.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12591648

Brand

GM

Year

2006

Model

isuzu-i-280

Hardware Type

Interchange part number

Manufacturer Part Number

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