2006 Isuzu I-350 Powertrain Control Module PCM 12606398

Restore Your Isuzu’s Performance & Reliability

Get your 2006 Isuzu I-350 running smoothly again with a powertrain control module programmed specifically to your VIN. This direct-fit PCM arrives with the latest GM software updates, ready for installation. Skip the expensive dealership trip and order yours today!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

Is Your Isuzu I-350 Running Rough? The PCM Might Be the Culprit.

The Powertrain Control Module (PCM), often called the Electronic Control Module (ECM), is the central brain of your 2006 Isuzu I-350. It manages everything from fuel injection and ignition timing to transmission shift points and emissions controls. When this critical component begins to fail, it can cause a cascade of confusing and frustrating problems, leaving you stranded or dealing with a vehicle that’s unreliable and inefficient. If you’re experiencing erratic engine behavior, poor performance, or an illuminated Check Engine Light that won’t go away, a failing PCM is a likely cause.

This isn’t just a replacement part; it’s a complete solution. We provide a fully programmed powertrain control module specifically for your vehicle. By providing us with your Vehicle Identification Number (VIN) during checkout, you receive a unit that is flashed with the latest GM factory updates. This ensures optimal performance, fuel efficiency, and emissions compliance right out of the box, eliminating the need for an expensive trip to the dealership for programming.

From the Diagnostic Bay

We had a 2006 Chevy Colorado (which shares a platform with the I-350) come into the shop with a persistent P0300 random misfire code. The owner had already replaced all the spark plugs, coils, and even the fuel injectors, spending hundreds of dollars with no success. The truck idled poorly and hesitated on acceleration. After hooking up our professional scan tool and monitoring live data, we noticed the fuel trim and ignition timing commands from the PCM were erratic and inconsistent. We suspected the PCM’s internal logic was failing. After installing one of our VIN-programmed modules, the engine immediately smoothed out, and the misfire code never returned. It’s a classic case where chasing individual parts was a waste of time and money; the root cause was the computer itself.

Is Your Isuzu I-350 Showing Signs of PCM Failure?

  • ✔ Persistent Check Engine Light (CEL) with various trouble codes.
  • ✔ Engine stalling, stuttering, or hesitating during acceleration.
  • ✔ Noticeable decrease in fuel economy.
  • ✔ Harsh or erratic automatic transmission shifting.
  • ✔ The engine cranks but refuses to start (no-start condition).
  • ✔ Communication errors with diagnostic scan tools.
  • ✔ Failure to pass state emissions testing.

The Direct-Fit, Programmed Solution for Your Truck

Replacing the brain of your vehicle sounds intimidating, but we make it simple. This module is a direct replacement for a wide range of original part numbers, including 12569773, 12597521, 12606398, and many more, ensuring broad compatibility. Our process is designed for the DIY mechanic and professional alike. You order the part, provide your VIN, and we handle the complex programming. The part you receive is ready for installation. In most cases, it’s a simple plug-and-play process, though some vehicles may require a straightforward security relearn procedure (often called a CASE relearn), which can typically be done without special tools.

Why Choose a VIN-Programmed 2006 Isuzu I-350 PCM?

Generic, non-programmed modules from a local auto parts store or salvage yard simply will not work. Your truck’s PCM is tied to its specific VIN, which contains information about its engine, transmission, and factory options. Without correct programming, the vehicle’s anti-theft system will engage, preventing it from starting. Our service bridges that gap, providing a cost-effective and reliable alternative to the dealership. We ensure the 2006 Isuzu I-350 PCM you receive is perfectly matched to your truck’s specifications, restoring its original performance and reliability.

This module is compatible with a variety of GM trucks and SUVs from the same era, including:

  • 2004-2006 Chevrolet Colorado & GMC Canyon
  • 2006 Hummer H3
  • 2006 Buick Rainier, Chevrolet Trailblazer, GMC Envoy (4.2L)
  • 2006 Isuzu Ascender (4.2L) & I-280
  • 2006 Saab 9-7X (6 cylinder)

Frequently Asked Questions

Do I need to get this module programmed by a dealer?

No. This module comes fully programmed to your vehicle’s specific VIN before we ship it. This service is included in the purchase price, saving you time and the high cost of dealership programming.

Where is the PCM located on my 2006 Isuzu I-350?

On the 2006 Isuzu I-350, as well as the Chevy Colorado and GMC Canyon, the Electronic Control Module is typically located on the right-hand (passenger) side of the firewall in the engine bay.

What happens if I forget to provide my VIN?

Providing your VIN is a mandatory step. We cannot program or ship your module without it. After your purchase, we will contact you to obtain the VIN if it wasn’t included in the order notes. The sooner we get your VIN, the sooner we can ship your part.

Will this fix my check engine light?

If the check engine light is caused by a faulty PCM, then yes, this part will resolve the issue. However, it is crucial to perform a proper diagnosis to confirm the PCM is the root cause and not a separate sensor or wiring problem.

Is any other procedure required after installation?

In some cases, a security relearn or a Crankshaft Variation (CASE) relearn procedure may be necessary after installation. These procedures sync the new module with your vehicle’s anti-theft system and crankshaft position sensor. Many can be performed without special tools, and we can provide instructions upon request.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12606398

Brand

GM

Year

2006

Model

isuzu-i-350

Hardware Type

Interchange part number

Manufacturer Part Number

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