Is Your Isuzu I-350 Running Rough? The PCM Might Be the Culprit.
If you’re experiencing frustrating and unpredictable issues with your 2006 Isuzu I-350, such as a persistent Check Engine Light, poor fuel economy, or erratic engine behavior, the root cause is often the Powertrain Control Module (PCM). As the central computer of your truck, the PCM is responsible for managing everything from fuel injection and ignition timing to transmission shifting and emissions control. When it begins to fail, it can create a cascade of problems that are difficult to diagnose and can leave your vehicle unreliable or even undrivable.
This replacement Powertrain Control Module, part number 12589585, is the definitive solution to restore your vehicle’s performance and reliability. Unlike generic modules that require expensive trips to the dealership for programming, this unit arrives at your door fully programmed to your truck’s specific Vehicle Identification Number (VIN). We install the latest GM-authorized software updates, which can resolve underlying factory issues and improve overall engine and transmission operation. This ensures a seamless installation process and gets you back on the road quickly.
From the Diagnostic Bay
We had a 2006 Chevy Colorado (which shares this exact PCM with the Isuzu I-350) come into the shop with a bizarre issue. The owner complained of random stalling at stoplights and a transmission that seemed to have a mind of its own, shifting harshly one minute and perfectly the next. He had already replaced the throttle body and a transmission solenoid pack with no improvement. After running diagnostics, we found no hard codes, just intermittent communication errors with the PCM. On a hunch, we swapped in a known-good, programmed module. The truck immediately ran like new. The original PCM had internal circuit board failures that were heat-sensitive, causing these ghost-like problems that no single sensor replacement could fix. It’s a classic case of the vehicle’s ‘brain’ being the source of the trouble.
Common Symptoms of a Failing 2006 Isuzu I-350 PCM
- ✔ Check Engine Light: The light is on, and you may have codes related to sensors, emissions, or internal module failure (e.g., P0601, P0606).
- ✔ Poor Engine Performance: Noticeable loss of power, hesitation during acceleration, or rough idling.
- ✔ Reduced Fuel Economy: Your truck may be consuming significantly more fuel than usual as the PCM can no longer optimize the air-fuel mixture.
- ✔ Transmission Issues: Harsh shifting, delayed engagement, or getting stuck in a single gear (limp mode).
- ✔ No-Start Condition: The engine cranks but refuses to start, or it starts and immediately stalls.
- ✔ Intermittent Stalling: The vehicle shuts off unexpectedly while driving or idling.
- ✔ Failed Emissions Test: Inability to pass a smog check due to PCM-related fault codes or monitor readiness issues.
The Plug-and-Play Advantage
The biggest challenge when replacing a modern vehicle computer is the programming. This module eliminates that hurdle. By providing us with your VIN during checkout, you receive a unit that is a direct-fit, pre-programmed replacement. Our process ensures that all the unique operational parameters for your specific Isuzu I-350 are correctly loaded. This includes information about your engine, transmission, tire size, and any factory-installed options. The result is a component that integrates perfectly with your truck’s existing systems, often performing better than the original due to the updated software.
This PCM is a direct replacement for a wide range of part numbers, ensuring broad compatibility across several GM and Isuzu platforms. Please verify that your original part number is on the list below for a guaranteed match:
Compatible Part Numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.
Frequently Asked Questions
Do I need to do any programming after I receive the module?
No! This module comes fully programmed to your vehicle’s VIN. In most cases, it is a simple plug-and-play installation. However, some vehicles may require a security relearn procedure (also known as a CASE relearn), which can typically be done without special tools and takes about 30 minutes. Instructions are readily available online for this process.
How do I provide my VIN?
After you complete your purchase, you will receive instructions on how to send us your vehicle’s 17-digit VIN. We cannot ship your part until we receive this information, as the programming is specific to your truck.
Is this a new or used part?
This is a high-quality, genuine OEM part that has been meticulously inspected, tested, and prepared for your vehicle. It is programmed with the latest software from GM to ensure optimal performance and longevity.
Where is the PCM located on my 2006 Isuzu I-350?
On the 2006 Isuzu I-350, as well as the Chevy Colorado and GMC Canyon, the Electronic Control Module is typically located on the right-hand (passenger) side of the firewall in the engine bay.
What if my part number is not on your list?
If your part number is not listed, please contact us with your vehicle’s information. We have a vast inventory and can help you find the correct module for your specific application.