Is Your Isuzu I-350 Running Rough? The PCM Might Be the Culprit.
If you’re experiencing baffling engine problems with your 2006 Isuzu I-350, from a persistent check engine light to unpredictable stalling or poor fuel economy, the root cause is often the vehicle’s brain: the Powertrain Control Module (PCM). This critical component manages everything from fuel injection and ignition timing to transmission shifting. When it fails, it can create a cascade of frustrating and difficult-to-diagnose issues. Don’t let a faulty computer keep your reliable truck off the road. This direct-replacement PCM, part number 12606369, is the definitive solution to restore your vehicle’s performance and reliability.
From the Diagnostic Bay
We had a 2006 Chevy Colorado (which shares the same platform and PCM as the I-350) come into the shop with a really strange issue. The owner complained of random stalling, but only after driving for 20 minutes and only on hot days. There were no consistent trouble codes, just a generic communication error that would pop up occasionally. We checked wiring, sensors, and fuel pressure—everything seemed fine. On a hunch, we swapped in one of our pre-programmed PCMs. The problem vanished instantly. The original module had an internal fault that only manifested under specific temperature conditions. It’s a classic example of how a failing PCM can send you chasing ghosts for days, when the real solution is a reliable, correctly programmed replacement.
Symptoms of a Failing 2006 Isuzu I-350 PCM
A failing powertrain control module can manifest in various ways. If you’re noticing any of the following symptoms, it’s a strong indicator that your PCM needs attention. Ignoring these signs can lead to further component damage, failed emissions tests, and even leave you stranded.
- ✔ Persistent Check Engine Light (CEL) that won’t clear or returns with various codes.
- ✔ Unexplained drop in fuel efficiency.
- ✔ Rough or erratic engine idling.
- ✔ Harsh or delayed automatic transmission shifting.
- ✔ Engine stalling, hesitation, or misfiring.
- ✔ The vehicle cranks but refuses to start.
- ✔ Communication errors with diagnostic scan tools.
- ✔ Failure to pass state emissions testing.
The Plug-and-Play Solution: Programmed to Your VIN
What sets this module apart is our professional programming service. We don’t just send you a part; we deliver a ready-to-install solution. When you order, you provide us with your vehicle’s 17-digit Vehicle Identification Number (VIN). Our technicians then use that VIN to flash the module with the latest, most stable software updates directly from GM. This process ensures the PCM is perfectly matched to your truck’s specific configuration, including its engine, transmission, and factory options. This eliminates the need for an expensive trip to the dealership for programming, saving you time and money. The module arrives at your door ready for a straightforward, plug-and-play installation.
Guaranteed Fitment for a Wide Range of GM Vehicles
This electronic control module is a direct replacement for a variety of GM trucks and SUVs. Please verify your vehicle and options below. This unit is compatible with the following part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.
- CHEVROLET COLORADO 2004-2006 (Electronic Control Module; RH firewall)
- CHEVROLET TRAILBLAZER & TRAILBLAZER EXT 2006 (Electronic Control Module; LH engine, 4.2L)
- GMC CANYON 2004-2006 (Electronic Control Module; RH firewall)
- GMC ENVOY & ENVOY XL 2006 (Electronic Control Module; 4.2L, LH engine)
- BUICK RAINIER 2006 (Electronic Control Module; LH engine, 4.2L)
- HUMMER H3 2006 (Electronic Control Module; RH firewall)
- ISUZU ASCENDER 2006 (Electronic Control Module; 4.2L, LH engine)
- ISUZU I-280 2006 (Electronic Control Module; RH firewall)
- ISUZU I-350 2006 (Electronic Control Module; RH firewall)
- SAAB 9-7X 2006 (Electronic Control Module; LH engine, 6 cylinder)
Frequently Asked Questions
Do I need to get this PCM programmed by a dealer?
No. This module comes fully programmed to your vehicle’s specific VIN before it ships. It is a plug-and-play solution, saving you the time and expense of a dealership visit.
What is a VIN and why do you need it?
The VIN (Vehicle Identification Number) is a unique 17-digit code for your specific truck. We use it to load the exact factory software and calibrations your vehicle requires, ensuring perfect communication with all other onboard systems.
Where is the PCM located on my 2006 Isuzu I-350?
On the 2006 Isuzu I-350, as well as the Chevy Colorado and GMC Canyon, the PCM is typically located on the right-hand (passenger side) of the firewall in the engine bay.
Will this fix my check engine light?
If the check engine light is caused by a faulty PCM, then yes, this part will resolve the issue. However, the check engine light can be triggered by many other failing components. It’s always best to have the codes read by a scanner to help diagnose the problem.
Is any other procedure required after installation?
In some cases, a Crankshaft Variation Relearn (also known as a CASE relearn) may be required to prevent a P1336 trouble code. This procedure can be performed with most professional-grade scan tools and is a simple process. Some vehicles may also require a security relearn, which typically involves cycling the key in the ignition.