2006 Isuzu I-350 PCM Powertrain Control Module 12597521

Restore Your Isuzu’s Performance!

Get your 2006 Isuzu I-350 back on the road fast with a powertrain control module programmed specifically for your VIN. This direct-fit PCM arrives with the latest GM software, ready for installation. Provide your VIN at checkout and let us handle the rest!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



SKU: 590-00320-24 Categories: ,
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Is Your 2006 Isuzu I-350 Running Rough? The PCM Might Be the Culprit.

The Powertrain Control Module (PCM), often called the Electronic Control Module (ECM), is the central brain of your 2006 Isuzu I-350. It manages everything from fuel injection and ignition timing to transmission shifting and emissions control. When this critical component begins to fail, it can cause a wide range of frustrating and often misdiagnosed issues, leaving your reliable truck feeling unpredictable or even undrivable. If you’re dealing with persistent check engine lights, poor fuel economy, or erratic engine behavior, you’ve come to the right place for a dependable solution.

This isn’t just a replacement part; it’s a fully programmed, ready-to-install solution for your vehicle. We take the guesswork and expensive dealership trips out of the equation. By providing us with your vehicle’s VIN (Vehicle Identification Number) during checkout, you receive a module that is flashed with the latest official GM software updates specifically for your truck’s configuration. This ensures optimal performance, fuel efficiency, and compatibility right out of the box.

Expert Pro Tip
Before condemning your PCM, always perform a thorough check of your vehicle’s battery, alternator, and all primary ground connections. A weak battery or a corroded ground strap can cause low voltage issues that mimic PCM failure, leading to erratic behavior and false diagnostic codes. A few minutes with a multimeter can save you from replacing a perfectly good module.

Common Symptoms of a Failing Powertrain Control Module

A faulty PCM can manifest in numerous ways. If your Isuzu I-350 is experiencing any of the following, a failing module could be the root cause:

  • ✔ Persistent Check Engine Light (CEL) that won’t clear or returns immediately.
  • ✔ Unexplained drop in fuel economy.
  • ✔ Rough or inconsistent engine idling.
  • ✔ Hesitation or stumbling during acceleration.
  • ✔ Harsh or erratic automatic transmission shifting.
  • ✔ Engine stalling for no apparent reason.
  • ✔ Complete no-start condition where the engine cranks but won’t fire.
  • ✔ Communication errors with diagnostic scan tools.

The Right Solution: A Programmed 2006 Isuzu I-350 PCM

Replacing a modern vehicle’s computer isn’t as simple as swapping parts. The PCM is intrinsically linked to your truck’s security system (Passlock/VATS) and other onboard modules. Our service simplifies this complex process. We handle the critical programming phase, ensuring the module you receive is a direct fit, both physically and electronically. This pre-programming service saves you hundreds of dollars in dealership labor and specialized tool costs. Once installed, you may only need to perform a simple security relearn procedure, which can often be done without any special tools.

This module is a direct replacement for a wide range of original equipment part numbers, guaranteeing broad compatibility across several GM platforms. Restoring your vehicle’s performance and reliability is our top priority.

Guaranteed Fitment for Multiple Vehicles and Part Numbers:

This PCM is compatible with the following part numbers:

12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821

It is also confirmed to fit the following vehicles:

  • 2004-2006 Chevrolet Colorado
  • 2004-2006 GMC Canyon
  • 2006 Buick Rainier (4.2L)
  • 2006 Hummer H3
  • 2006 Isuzu Ascender (4.2L)
  • 2006 Isuzu I-280
  • 2006 Isuzu I-350
  • 2006 Chevrolet Trailblazer & Trailblazer EXT (4.2L)
  • 2006 GMC Envoy & Envoy XL (4.2L)
  • 2006 Saab 9-7X (6 cylinder)

Frequently Asked Questions

Do I need to program this PCM?

No. This module comes pre-programmed to your vehicle’s specific VIN. We flash it with the latest GM software updates before it ships, making it ready for installation.

What information do you need from me?

After you place your order, you will need to provide us with your 17-digit Vehicle Identification Number (VIN). This is crucial for us to load the correct software for your truck’s specific options and configuration.

Will this fix my vehicle’s problem for sure?

This part will resolve any issues directly caused by a faulty PCM. However, it’s essential that your vehicle has been properly diagnosed. This module will not fix problems related to other faulty sensors, wiring, or mechanical components.

Is any additional procedure needed after I install it?

In most cases, you will need to perform a security relearn procedure (also known as a VATS or Passlock relearn). This syncs the new PCM with your vehicle’s anti-theft system and can typically be done without special tools. Instructions are widely available online or in service manuals. A CASE relearn may also be required with a capable scan tool.

Where is the PCM located on my 2006 Isuzu I-350?

On the 2006 Isuzu I-350, as well as the Chevrolet Colorado and GMC Canyon, the Electronic Control Module is typically located on the right-hand (passenger) side of the firewall in the engine bay.

Condition

Refurbished

Year
Genuine OEM

Yes

MPN

12597521

Brand

GM

Year

2006

Model

isuzu-i-350

Hardware Type

Interchange part number

Manufacturer Part Number

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