2006 Isuzu I-350 PCM 12606373 | Pre-Flashed with Your VIN for Easy Install

Restore Your Isuzu’s Peak Performance!

Get your truck running right again with this Powertrain Control Module, pre-programmed to your vehicle’s VIN. It arrives with the latest GM software updates, ensuring a perfect fit and function for your 2006 Isuzu I-350. Eliminate frustrating engine problems and get back on the road fast. Order today!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

Restore Your Truck’s Brain and Bring Back Peak Performance

Is your 2006 Isuzu I-350 running rough, stalling unexpectedly, or showing a persistent Check Engine Light? The Powertrain Control Module (PCM) is the central computer of your vehicle, managing everything from fuel mixture and ignition timing to transmission shifting. When it fails, it can cause a cascade of frustrating and seemingly unrelated problems. This isn’t just an inconvenience; it’s a matter of reliability and safety. Get back the confidence of a vehicle that starts, runs, and performs exactly as it should with our expertly programmed PCM.

We take the guesswork and high dealership costs out of the equation. This module is not just a replacement part; it’s a complete solution. Upon purchase, you simply provide us with your vehicle’s VIN. Our technicians will then flash the module with the latest, most stable GM software updates specific to your truck. It arrives at your door ready to install, helping you get back on the road quickly and with peace of mind.

Warning Signs Your PCM is Failing and How This Solves Them

  • ✔ Persistent Check Engine Light: Often with codes related to module communication (e.g., U0100) or multiple, unrelated sensor faults.
  • ✔ Engine Performance Problems: Experiencing rough idling, stalling, hesitation during acceleration, or a noticeable drop in fuel economy.
  • ✔ No-Start Condition: The engine cranks but refuses to start, even with a good battery and starter.
  • ✔ Erratic Transmission Shifting: Harsh shifts, getting stuck in gear, or other automatic transmission issues can be directly linked to a faulty PCM.
  • ✔ Failed Emissions Test: A malfunctioning module can prevent your vehicle from passing mandatory emissions inspections.

A Mechanic’s Note: The Ghost in the Machine

“I once had a customer with a 2006 Canyon—a sibling to the I-350—that had the most bizarre intermittent stalling issue. It would run perfectly for days, then die at a stoplight without warning. They had replaced half a dozen sensors chasing the problem. We finally traced it to a PCM that was failing internally when it got hot. Swapping in a properly programmed module wasn’t just a fix; it was a relief. The customer finally got their reliable work truck back. That’s the power of addressing the core issue correctly the first time.”

Guided Installation for a Confident Repair

Replacing your 2006 Isuzu I-350 PCM is a straightforward job that most DIYers can handle with basic tools. Follow these steps for a smooth installation.

  1. Safety First: Always disconnect the negative terminal from your vehicle’s battery and wait at least 15 minutes to allow the system to fully discharge.
  2. Locate the Module: On your Isuzu I-350, the PCM is typically located on the right-hand (passenger) side of the firewall in the engine bay.
  3. Disconnect Connectors: Carefully unclip and remove the electrical wiring harnesses from the old PCM. Inspect the connectors for any corrosion or damaged pins.
  4. Swap the Units: Unbolt and remove the old module from its mounting bracket. Secure the new, pre-programmed module in its place.
  5. Reconnect Everything: Firmly plug the wiring harnesses into the new PCM until they click securely into place. Reconnect your battery terminal.
  6. Final Steps: Your vehicle may require a security relearn procedure (often called a Passlock relearn), which typically involves cycling the key in the ignition. Consult your owner’s manual or a reliable online resource for the specific steps for your truck. This ensures your vehicle recognizes the new module.

Guaranteed Fit for Your Vehicle

This Powertrain Control Module is a direct-fit replacement for the original, ensuring seamless integration. It is compatible with the following vehicles and part numbers:

This unit is a direct replacement for part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821

Fits these models:

  • COLORADO 04-06 (RH firewall)
  • RAINIER 06 (LH engine, 4.2L)
  • HUMMER H3 06 (RH firewall)
  • ISUZU ASCENDER 06 (4.2L, LH engine)
  • ISUZU I-350 06 (RH firewall)
  • TRAILBLAZER & TRAILBLAZER EXT 06 (4.2L, LH engine)
  • ENVOY & ENVOY XL 06 (4.2L, LH engine)
  • ISUZU I-280 06 (RH firewall)
  • SAAB 9-7X 06 (6 cylinder, LH engine)
  • CANYON 04-06 (RH firewall)

By ordering this pre-flashed 2006 Isuzu I-350 PCM, you’re not just buying a part—you’re investing in the renewed health and dependability of your truck.

Frequently Asked Questions

What is a PCM and what does it do?

The Powertrain Control Module (PCM) is your vehicle’s main computer. It controls the engine and transmission functions, managing fuel injection, spark timing, emissions systems, and shift points to ensure optimal performance, fuel efficiency, and low emissions.

How do I provide my VIN for programming?

After you complete your purchase, you will receive an email with instructions on how to reply with your vehicle’s 17-digit Vehicle Identification Number (VIN). We cannot ship your part until we receive this information, as the programming is specific to your truck.

Is this part truly plug-and-play?

Because we program the module to your VIN, it is designed to be as close to plug-and-play as possible. However, many GM vehicles of this era require a simple ‘security relearn’ procedure after installation to sync the new PCM with your vehicle’s anti-theft system. This can usually be done in your driveway without special tools.

Will this fix my transmission shifting problems?

In many cases, yes. The PCM directly controls the transmission’s electronic solenoids and shifting logic. If your transmission issues are caused by a faulty module, this replacement will resolve them. However, it will not fix mechanical issues within the transmission itself.

What if I have questions during installation?

Our team of experienced technicians is here to help. Your purchase includes access to our support, so if you encounter any issues or have questions during the process, please don’t hesitate to contact us.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12606373

Brand

GM

Year

2006

Model

isuzu-i-350

Hardware Type

Interchange part number

Manufacturer Part Number

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