Restore Peak Performance to Your Isuzu Truck
If you’re dealing with a frustrating check engine light, erratic engine behavior, or a no-start condition in your 2006 Isuzu I-350, a failing Powertrain Control Module (PCM) is often the culprit. As the central computer for your engine and transmission, its health is non-negotiable. I’ve spent two decades under the hood, and I can tell you that chasing intermittent electronic gremlins is one of the most maddening diagnostic challenges. This replacement PCM is the definitive solution, arriving at your door programmed with the latest GM software updates specifically for your truck’s VIN. This eliminates the need for expensive dealership programming, getting you back on the road with confidence and reliability.
From the Diagnostic Bay: The Intermittent Stall Case
I once had a 2006 Chevy Colorado (which shares this exact platform) in my shop with a problem that drove the owner crazy. It would run perfectly for days, then suddenly stall at a stoplight and refuse to restart for 20 minutes. No consistent codes, just a U0100 (Lost Communication with ECM/PCM) that would pop up sporadically. After checking all the usual suspects—wiring harnesses, grounds, fuel pressure—I noticed the stalls only happened on hot days after a long drive. On a hunch, I used a heat gun on the PCM, located on the RH firewall. Sure enough, after a few minutes of heat, the engine sputtered and died. The internal circuits were failing under thermal stress. A new, properly programmed PCM like this one solved the issue permanently. It’s a classic failure mode for these units.
Is Your Truck’s Computer Showing These Signs?
- ✔ Persistent Check Engine Light (CEL) with communication or processor codes (e.g., P0601, P0606, U0100).
- ✔ Unexplained stalling or engine hesitation, especially when warm.
- ✔ Rough or inconsistent idling.
- ✔ Noticeable decrease in fuel economy.
- ✔ Harsh or erratic automatic transmission shifting.
- ✔ Complete no-start condition where the engine cranks but won’t fire.
- ✔ Other warning lights on the dash, such as ABS or traction control, due to lost communication.
A Straightforward Guide to Installation
- ✔ Safety First: Always disconnect the negative terminal from your vehicle’s battery and wait at least 10 minutes for capacitors to discharge.
- ✔ Locate the Module: On your Isuzu I-350, the PCM is typically mounted on the right-hand (passenger side) firewall in the engine bay.
- ✔ Disconnect Connectors: Carefully release the locking tabs on the electrical wiring harnesses and pull them straight out from the module. Never force them. Inspect connectors for any corrosion or damage.
- ✔ Remove the Old PCM: Unbolt the mounting hardware holding the old module in place and remove it from the vehicle.
- ✔ Install the New PCM: Mount your new, pre-programmed PCM using the original hardware. Ensure it is secure.
- ✔ Reconnect Everything: Firmly plug the wiring harnesses back into the new module until they click into place. Reconnect the negative battery terminal.
- ✔ Final Steps: Your vehicle may need to complete a security relearn procedure, which is often as simple as turning the key to the ‘ON’ position for 10-15 minutes before starting. Your truck is now ready to go!
By ordering this 2006 Isuzu I-350 PCM, you’re not just buying a part; you’re getting a complete, ready-to-install fix. We handle the complex programming so you can handle the simple installation. This module is also a direct replacement for a wide range of part numbers, ensuring broad compatibility.
Verified Vehicle Compatibility
This module is guaranteed to fit the following vehicles. Please verify your model and engine options.
- Chevrolet Colorado: 2004-2006 (Electronic Control Module; RH firewall)
- GMC Canyon: 2004-2006 (Electronic Control Module; RH firewall)
- Hummer H3: 2006 (Electronic Control Module; RH firewall)
- Isuzu I-280: 2006 (Electronic Control Module; RH firewall)
- Isuzu I-350: 2006 (Electronic Control Module; RH firewall)
- Buick Rainier: 2006 (Electronic Control Module; LH engine, 4.2L)
- Chevrolet Trailblazer: 2006 (Electronic Control Module; LH engine, 4.2L)
- Chevrolet Trailblazer EXT: 2006 (Electronic Control Module; LH engine, 4.2L)
- GMC Envoy: 2006 (Electronic Control Module; 4.2L, LH engine)
- GMC Envoy XL: 2006 (Electronic Control Module; LH engine, 4.2L)
- Isuzu Ascender: 2006 (Electronic Control Module; 4.2L, LH engine)
- Saab 9-7X: 2006 (Electronic Control Module; LH engine, 6 cylinder, ID 12569773 or 12597521)
This part replaces the following service numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.
Why do you need my VIN?
Why do you need my VIN?
Your Vehicle Identification Number (VIN) is essential because it allows us to load the exact, factory-correct software for your truck’s specific options, engine, and transmission. This ensures perfect communication between all vehicle modules and guarantees optimal performance right out of the box.
Is this a plug-and-play part?
Yes, for most vehicles on the fitment list. Because we program it to your VIN, it is ready for installation with no dealer visit required. Some vehicles may require a simple, key-on security relearn procedure that you can do yourself in your driveway.
What if my original part number is not on your list?
The part numbers listed are the most common, but there can be others. As long as your vehicle—make, model, year, and engine—is on our compatibility list, this module will be the correct replacement. The VIN programming ensures it will work for your specific application.
Will this fix my check engine light?
If your check engine light is caused by an internal PCM failure (like codes P0601 or P0606), then yes, this will resolve the issue. However, if the code is for a faulty sensor (like an O2 sensor or MAP sensor), you will still need to replace that sensor. This PCM will only fix problems originating from the module itself.