Is Your 2006 Isuzu I-280 Running Rough or Not Starting at All?
As a technician with over two decades of experience under the hood, I’ve seen firsthand how a failing Powertrain Control Module (PCM) can bring a perfectly good truck to a dead stop. For owners of the 2006 Isuzu I-280 and its sister vehicles like the Chevy Colorado and GMC Canyon, a faulty PCM isn’t just an inconvenience—it’s a frustrating diagnostic puzzle that can manifest in confusing ways.
Common Symptoms of a Failing PCM on Your Truck
If your I-280 is experiencing any of the following issues, the PCM is a very likely culprit. In my shop, I’ve diagnosed hundreds of these GMT355 platform trucks, and these symptoms are the classic tell-tale signs of internal module failure.
- ✔ An engine that cranks but refuses to start.
- ✔ The dreaded Check Engine Light is on with communication-related codes (U-codes) or internal processor fault codes (P0601, P0606).
- ✔ Harsh or erratic automatic transmission shifting.
- ✔ Stalling for no apparent reason, either at idle or while driving.
- ✔ A noticeable drop in fuel economy.
- ✔ The security or anti-theft light may be illuminated on the dash, preventing startup.
A Technician’s Real-World Story
“A customer’s 2006 Isuzu I-280 came in last week on a tow truck. It would crank all day but never fire up. The owner had already replaced the battery and checked the fuel pump, but nothing worked. When I connected my scan tool, I couldn’t communicate with the PCM at all—a dead giveaway. We located the module on the right-hand firewall, and upon inspection, there were no obvious signs of damage. However, an internal processor failure had completely bricked the unit. We installed one of our pre-programmed modules, and the truck fired up on the first try. It’s a common failure point I’ve seen dozens of times on these trucks.”
The Direct Solution: A VIN-Programmed PCM
Don’t let a bad computer keep your truck off the road. This Powertrain Control Module is the reliable, straightforward solution to get your Isuzu I-280 running properly again. The biggest hurdle with replacing a modern vehicle computer is the need for expensive, dealer-specific programming. We eliminate that step entirely.
When you order from us, you provide your vehicle’s 17-digit VIN. We then flash the module with the latest, most stable software release from GM specifically for your truck’s configuration. This ensures perfect compatibility and function right out of the box.
- ✔ No Dealer Visit Required: This module arrives ready to install. Simply disconnect the battery, swap the part, and reconnect.
- ✔ Latest GM Software: We program it with the newest updates, which often correct factory bugs related to engine performance and transmission logic.
- ✔ Guaranteed Compatibility: By using your VIN, we ensure the programming matches your engine, transmission, and other vehicle options perfectly.
Installation & Location
On the 2006 Isuzu I-280, the PCM is typically located in the engine bay, mounted to the firewall on the passenger’s side (RH side). Installation is manageable for a DIYer with basic tools. Always disconnect the negative battery terminal before starting any work on the electrical system.
Guaranteed Fitment for a Wide Range of GM Vehicles
This module is a direct replacement for part number 19209821 and interchanges with a variety of other part numbers. It fits a broad family of GM trucks and SUVs. Please verify your vehicle is on this list:
Trucks (RH Firewall Location)
- ✔ 2004-2006 Chevrolet Colorado
- ✔ 2004-2006 GMC Canyon
- ✔ 2006 Hummer H3
- ✔ 2006 Isuzu I-280
- ✔ 2006 Isuzu I-350
SUVs (LH Engine/Fender Location)
- ✔ 2006 Buick Rainier (4.2L)
- ✔ 2006 Chevrolet Trailblazer & Trailblazer EXT (4.2L)
- ✔ 2006 GMC Envoy & Envoy XL (4.2L)
- ✔ 2006 Isuzu Ascender (4.2L)
- ✔ 2006 Saab 9-7X (6 Cylinder)
This unit replaces the following part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821.