2006 Isuzu I-280 PCM Powertrain Control Module 12597521

Restore Your Truck’s Performance!

Get a reliable, VIN-programmed Powertrain Control Module for your 2006 Isuzu I-280. This PCM solves common issues like stalling, rough idling, and check engine lights. It arrives ready to install with the latest GM software. Provide your VIN at checkout and get back on the road fast!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



SKU: 590-00320-25 Categories: ,
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Is Your Isuzu I-280 Running Rough? The PCM Might Be the Culprit.

The Powertrain Control Module, or PCM, is the central command center for your 2006 Isuzu I-280’s engine and transmission. It processes data from dozens of sensors to manage critical functions like fuel injection, ignition timing, and transmission shift points. When this vital component begins to fail, it can cause a wide range of frustrating and often mysterious performance issues, from a simple check engine light to a vehicle that won’t start at all. If you’re tired of chasing down phantom problems, this pre-programmed PCM is the definitive solution to restore your truck’s reliability and performance.

From the Diagnostic Bay

We once had a 2006 GMC Canyon (which uses the same platform as the I-280) come into the shop with an intermittent stalling issue. The owner had already replaced the crankshaft position sensor, camshaft position sensor, and the throttle body based on various forum suggestions, spending hundreds of dollars with no success. After connecting our diagnostic scanner, we noticed erratic data streams coming from the PCM itself. A quick check of the wiring confirmed the module was faulty. We installed a VIN-programmed PCM just like this one, performed the security relearn, and the truck ran perfectly. It’s a classic case of symptoms pointing to sensors when the root cause is the computer processing the data.

Symptoms of a Failing Powertrain Control Module

A failing PCM can manifest in numerous ways. If your vehicle is experiencing any of the following, it’s a strong indicator that your engine computer needs replacement:

  • ✔ Persistent Check Engine Light (CEL) with various trouble codes.
  • ✔ Engine stalling or shutting off unexpectedly while driving.
  • ✔ Rough or erratic idling.
  • ✔ Noticeable decrease in fuel economy.
  • ✔ Harsh or incorrect automatic transmission shifting.
  • ✔ Engine misfires or hesitation during acceleration.
  • ✔ Complete no-start condition where the engine cranks but won’t turn over.
  • ✔ Communication errors with diagnostic scan tools.

Why Choose Our Programmed 2006 Isuzu I-280 PCM?

This isn’t just a replacement part; it’s a complete, ready-to-install solution. We take the guesswork and hassle out of the repair process. When you order from us, we flash the module with the latest, most stable software updates directly from GM, tailored specifically to your vehicle’s Vehicle Identification Number (VIN). This ensures that all factory parameters are correctly set for your truck’s specific engine, transmission, and options. This process eliminates the need for an expensive trip to the dealership for programming, saving you both time and money.

Plug-and-Play Installation Process

Our goal is to make your repair as straightforward as possible. Once you receive your VIN-programmed module, the installation is simple:

  1. Disconnect the Battery: Always disconnect the negative battery terminal before working on your vehicle’s electronics.
  2. Locate and Replace the PCM: On the 2006 Isuzu I-280, the PCM is typically located on the right-hand (passenger side) firewall in the engine bay. Disconnect the electrical connectors and unbolt the old module.
  3. Install the New Module: Bolt the new PCM into place and securely reconnect the electrical harnesses.
  4. Reconnect the Battery: Reattach the negative battery terminal.
  5. Perform Security Relearn: In most cases, you will need to perform a simple security relearn procedure (often called a Passlock or anti-theft relearn) to sync the new PCM with your vehicle’s keys. This procedure can typically be done without special tools and involves a sequence of key turns. Instructions are widely available online or in your vehicle’s service manual.

This module is a direct replacement for a wide range of part numbers, ensuring broad compatibility across the GM mid-size truck and SUV platform. It fits not only the 2006 Isuzu I-280 but also the Chevy Colorado, GMC Canyon, Hummer H3, and various Trailblazer/Envoy models. Compatible part numbers include: 12569773, 12588650, 12589311, 12597521, 12600818, 19209820, and many more.

Frequently Asked Questions

What is a PCM and what does it do?

The Powertrain Control Module (PCM) is your vehicle’s main computer. It controls all aspects of engine and transmission operation to ensure optimal performance, fuel efficiency, and emissions control.

Do I need to have this module programmed?

No. We handle the programming for you before we ship the part. Simply provide us with your vehicle’s VIN during or after checkout, and it will arrive flashed with the latest GM software for your specific vehicle.

Where can I find my vehicle’s VIN?

Your 17-digit Vehicle Identification Number (VIN) can be found on your vehicle’s registration, insurance card, or on a metal plate on the driver’s side of the dashboard, visible through the windshield.

Is any other setup required after I install it?

After installation, you will likely need to perform a security relearn procedure to sync the new PCM with your vehicle’s anti-theft system. This is a simple procedure that usually takes about 30 minutes and does not require special tools. A Crankshaft Variation (CASE) relearn may also be needed, which requires a compatible scan tool.

Will this fix my check engine light?

If the check engine light is caused by a faulty PCM, then yes, this part will resolve the issue. However, it’s crucial to ensure the codes are not being caused by other failing components like sensors or wiring.

How do I know this part will fit my vehicle?

This PCM fits a 2006 Isuzu I-280 and many other GM models listed in the description. By programming the module to your specific VIN, we ensure it functions correctly for your vehicle’s exact configuration. It replaces a long list of original part numbers, including 12597521.

Condition

Refurbished

Year
Genuine OEM

Yes

MPN

12597521

Brand

GM

Year

2006

Model

isuzu-i-280

Hardware Type

Interchange part number

Manufacturer Part Number

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