2006 I-280 Engine Control Module 12606398 Programmed To Your VIN VIN ECM PCM ECU

Restore Your Truck’s Drivability

Get your Isuzu back on the road with this direct-fit Powertrain Control Module. It arrives fully programmed to your vehicle’s VIN with the latest GM software, eliminating dealer programming fees. Fix check engine lights, poor performance, and shifting issues today!

$184.95

+11.99 USPS Priority Shipping

Availability: In stock



Guaranteed Safe Checkout

Restore Peak Performance to Your Isuzu I-280

Is your 2006 Isuzu I-280 suffering from perplexing issues like a persistent check engine light, rough idling, stalling, or erratic transmission shifting? These are classic signs of a failing Powertrain Control Module (PCM), the central computer of your vehicle. Don’t let a faulty module keep your reliable truck off the road. This replacement PCM is the definitive solution, arriving at your door programmed with the latest GM software updates specifically for your vehicle’s VIN. This eliminates the need for expensive dealership programming and gets you back to driving with confidence.

From the Diagnostic Bay

We had a 2006 Chevy Colorado (which shares this exact PCM with the Isuzu I-280) come into the shop with a laundry list of complaints. The owner had already replaced the throttle body, mass airflow sensor, and all four O2 sensors trying to chase down a stubborn P0171 lean code and a harsh 1-2 shift. The truck ran fine for a day after each repair, then the problems returned. After confirming all sensor readings were plausible, we focused on the PCM. We swapped in one of our pre-programmed modules, performed the quick security relearn, and the truck immediately ran like new. The shifting smoothed out, the fuel trims stabilized, and the check engine light stayed off. It’s a textbook case of how a failing PCM can send you on an expensive wild goose chase, when the root cause is the computer itself.

Common Symptoms of a Failing PCM

  • ✔ Persistent Check Engine Light (CEL) with various trouble codes.
  • ✔ Unexplained drop in fuel economy.
  • ✔ Engine stalling, stumbling, or hesitating during acceleration.
  • ✔ Rough or inconsistent idling.
  • ✔ Harsh or delayed automatic transmission shifts.
  • ✔ Complete no-start or intermittent starting condition.
  • ✔ Communication errors with diagnostic scan tools.

Why Choose Our Programmed 2006 Isuzu I-280 PCM?

This isn’t just a replacement part; it’s a comprehensive, plug-and-play solution. We take the guesswork and hassle out of the repair. When you order, you provide us with your vehicle’s VIN. Our technicians then flash the module with the correct, factory-authorized software for your specific 2006 Isuzu I-280 PCM. This ensures that all engine, transmission, and emissions parameters are set perfectly for your truck’s configuration. The module arrives ready for installation, saving you a trip to the dealer and hundreds of dollars in programming fees.

Guaranteed Compatibility

This module is a direct replacement for a wide range of GM light trucks and SUVs from the mid-2000s. It is compatible with numerous original equipment part numbers, ensuring a perfect match. Please verify your original part number against this list for guaranteed fitment:

Compatible Part Numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, 12596783, 12596784, 12597521, 12597776, 12597777, 12600818, 12604438, 12604439, 12606369, 12606373, 12606374, 12606398, 12606399, 19209820, 19209821

Simple Installation Process

Replacing the PCM on your 2006 Isuzu I-280 is a straightforward job. The module is typically located on the right-hand (passenger) side of the firewall in the engine bay. After disconnecting the battery, you simply unplug the electrical connectors, unbolt the old module, and install the new one. In most cases, you will need to perform a simple security relearn procedure (often called a Passlock or CASE relearn) which can be done without any special tools and takes about 30 minutes. Instructions are readily available online for this common procedure. This final step syncs the new 2006 Isuzu I-280 PCM with your vehicle’s anti-theft system.

Frequently Asked Questions

What is a PCM and what does it do?

The Powertrain Control Module (PCM) is the main computer that controls your vehicle’s engine and transmission. It takes in data from dozens of sensors to manage fuel injection, ignition timing, emissions systems, and automatic transmission shift points to ensure optimal performance, fuel efficiency, and low emissions.

Do I need to do any programming myself?

No. This module comes fully programmed to your vehicle’s specific VIN. We handle all the flashing and software updates before it ships. The only thing you may need to do after installation is a security relearn procedure, which syncs the new computer to your vehicle’s anti-theft system and can be done without special tools.

Where is the PCM located on my 2006 Isuzu I-280?

On the 2006 Isuzu I-280, as well as the Chevy Colorado and GMC Canyon, the PCM (also called ECM) is located in the engine compartment on the right-hand (passenger side) firewall.

What is a “CASE relearn” and will I need one?

A CASE (Crankshaft Angle Sensor Error) relearn is a procedure that calibrates the new PCM to the slight variations in your engine’s crankshaft position sensor. While the vehicle will often run without it, performing this procedure with a capable scan tool is recommended for optimal performance and to prevent a potential check engine light for code P0315. Many local repair shops can perform this service quickly.

How can I be sure this part will fit my vehicle?

This PCM fits the 2006 Isuzu I-280 and many other GM models listed in the description. The best way to guarantee a match is to compare the part number on your original module to the list of compatible numbers provided in this listing. When you provide your VIN at checkout, we perform a final verification to ensure 100% compatibility.

Condition

Refurbished

Year

Genuine OEM

Yes

MPN

12606398

Brand

GM

Year

2006

Model

isuzu-i-280

Hardware Type

Interchange part number

Manufacturer Part Number

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