Restore Your Isuzu’s Core Performance and Reliability
If your 2006 Isuzu I-350 is suddenly giving you headaches with stalling, erratic shifting, or a check engine light that won’t go away, the problem often points directly to a failing Powertrain Control Module (PCM). As a technician with over 20 years of experience, I’ve seen firsthand how a faulty PCM can mimic a dozen other issues, leading to wasted time and money on unnecessary repairs. This replacement 2006 Isuzu I-350 PCM is the definitive solution to restore your truck’s engine and transmission management to factory specifications.
The PCM is the central computer of your vehicle, managing everything from fuel injection and spark timing to transmission shift points and emissions controls. When it begins to fail, the symptoms can be unpredictable and frustrating. This module is a direct-fit replacement, but with a crucial benefit: we program it specifically for your truck using your Vehicle Identification Number (VIN) before it ships. This means it arrives loaded with the latest GM software updates, ensuring optimal performance and eliminating the need for an expensive trip to the dealership for programming.
A Technician’s Notebook: The Intermittent Stall Mystery
I remember a 2006 Chevy Colorado (which uses this exact same PCM) that came into my shop with a maddening intermittent stalling issue. The owner had already replaced the fuel pump and crank sensor, but the truck would still die at random stoplights. My scan tool showed no hard codes, just a history of communication loss errors (U-codes). After checking the wiring harness for corrosion and finding nothing, I focused on the PCM. On these GM platforms, heat cycles and vibration can cause internal solder joints in the module to fail over time. We installed a pre-programmed PCM, performed the security relearn, and the truck ran perfectly. It’s a classic case where the “brain” itself was the culprit, and this is the fix that gets the job done right.
Is Your Truck Showing These Symptoms?
A failing PCM can cause a wide range of problems. If you’re experiencing any of the following, it’s a strong indicator that your engine computer needs replacement:
- âś” Unexplained Check Engine Light (CEL) illumination
- âś” Stalling, rough idling, or hesitation during acceleration
- âś” Poor fuel economy
- âś” Harsh or erratic automatic transmission shifting
- âś” Engine cranks but refuses to start
- âś” Diagnostic Trouble Codes (DTCs) such as P0601, P0606, or various communication errors (U-codes)
- âś” Failure to pass an emissions test
A Straightforward Guide to Installation
Installing your new 2006 Isuzu I-350 PCM is a job most DIYers can handle in under an hour. Since we program it for you, the process is greatly simplified.
- Safety First: Always disconnect the negative terminal from your vehicle’s battery before starting any electrical work.
- Locate the PCM: On the Isuzu I-350, the PCM is typically located on the right-hand (passenger side) of the firewall in the engine bay.
- Disconnect Connectors: Carefully unplug the electrical wiring harnesses from the old PCM. These connectors have locking tabs that need to be released. Avoid forcing them.
- Remove the Old Module: Unbolt the old PCM from its mounting bracket. It’s usually held in place by a few small bolts.
- Install the New Module: Mount your new, pre-programmed PCM onto the bracket and securely fasten it.
- Reconnect Everything: Plug the wiring harnesses firmly into the new module until they click into place. Reconnect the negative battery terminal.
- Perform Security Relearn: You will likely need to perform a simple security relearn procedure. This typically involves turning the key to the “ON” position for 10-15 minutes, then off, and repeating two more times. This allows the new PCM to sync with your vehicle’s anti-theft system. Consult your owner’s manual or a quick online search for your specific model’s procedure.
Verified Vehicle Compatibility
This powertrain control module is a guaranteed fit for a wide range of GM vehicles. Please verify your model and options below. This module replaces part numbers: 12569773, 12588650, 12589311, 12589585, 12591647, 12591648, 12593531, 12593532, 12594430, 12594431, and many more.
- Chevrolet Colorado 2004-2006 (RH firewall)
- GMC Canyon 2004-2006 (RH firewall)
- Hummer H3 2006 (RH firewall)
- Isuzu I-280 2006 (RH firewall)
- Isuzu I-350 2006 (RH firewall)
- Buick Rainier 2006 (4.2L, LH engine)
- Chevrolet Trailblazer & Trailblazer EXT 2006 (4.2L, LH engine)
- GMC Envoy & Envoy XL 2006 (4.2L, LH engine)
- Isuzu Ascender 2006 (4.2L, LH engine)
- Saab 9-7X 2006 (6-Cylinder)
Frequently Asked Questions About This 2006 Isuzu I-350 PCM
Frequently Asked Questions
Do I need to do any programming myself?
No. We handle all the programming for you before shipping. Simply provide your VIN during checkout, and the module will arrive ready for installation, loaded with the latest GM software for your specific vehicle.
What is a VIN and why do you need it?
VIN stands for Vehicle Identification Number. It’s a unique 17-digit code for your truck that contains information about its engine, transmission, and factory options. We use the VIN to ensure the programming is a perfect match for your vehicle’s configuration.
Is this a difficult part to replace for a DIYer?
Not at all. The physical replacement is straightforward, involving just a few bolts and electrical connectors. The most important step after installation is the security relearn procedure, which is simple and requires no special tools.
Will this fix my check engine light?
If the check engine light is caused by an internal PCM failure (like code P0601), then yes, this will resolve the issue. It’s always best to have the codes read with a scanner to confirm the diagnosis before ordering.
Is there a core charge for my old module?
This listing does not require a core return. You can keep or responsibly dispose of your old module without needing to send it back to us.